A novel synthesis of N-(piperidin-4-yl)-1,3-dihydroindol-2-one via an intramolecular Pd-catalyzed amination

[Display omitted] A novel efficient synthetic route to the pharmaceutical key intermediate N-(piperidin-4-yl)-1,3-dihydroindol-2-one is described. The key step involves a high-yielding intramolecular palladium-catalyzed amination reaction using Buchwald’s X-Phos ligand under mild reaction conditions...

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Bibliographic Details
Published in:Tetrahedron letters 2004-11, Vol.45 (46), p.8535-8537
Main Authors: van den Hoogenband, Adri, den Hartog, Jack A.J., Lange, Jos H.M., Terpstra, Jan Willem
Format: Article
Language:English
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Summary:[Display omitted] A novel efficient synthetic route to the pharmaceutical key intermediate N-(piperidin-4-yl)-1,3-dihydroindol-2-one is described. The key step involves a high-yielding intramolecular palladium-catalyzed amination reaction using Buchwald’s X-Phos ligand under mild reaction conditions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.09.121