Synthesis of chiral γ-lactams via Rh(II) catalyzed intramolecular C–H insertion: α-substituents and conformational effects

[Display omitted] Highly functionalized chiral γ-lactams are efficiently synthesized via Rh(II) catalyzed intramolecular C–H insertion from various α-diazoamides. Independent of α-substituents, regio- and stereoselectivities are enhanced through a conformational effect exerted by a bicyclic transiti...

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Bibliographic Details
Published in:Tetrahedron letters 2005-01, Vol.46 (1), p.143-146
Main Authors: Flanigan, David L., Yoon, Cheol Hwan, Jung, Kyung Woon
Format: Article
Language:English
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Summary:[Display omitted] Highly functionalized chiral γ-lactams are efficiently synthesized via Rh(II) catalyzed intramolecular C–H insertion from various α-diazoamides. Independent of α-substituents, regio- and stereoselectivities are enhanced through a conformational effect exerted by a bicyclic transition state.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.10.159