Solid-phase synthetic method for (±)-α-amino acids via phase-transfer catalytic alkylation

[Display omitted] A solid supported glycineimine t-butyl ester was designed and successfully applied to the synthesis of (±)-α-amino acids. The phase-transfer catalytic alkylation, followed by acidic hydrolysis and benzoylation gave N-benzoyl-α-amino acid tert-butyl esters in high yields (up to 92%)...

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Bibliographic Details
Published in:Tetrahedron letters 2005-01, Vol.46 (1), p.93-95
Main Authors: Park, Hyeung-geun, Kim, Mi-Jeong, Park, Mi-Kyung, Jung, Hyun-Ju, Lee, Jihye, Lee, Yeon-Ju, Jeong, Byeong-Seon, Lee, Jeong-Hee, Yoo, Mi-Sook, Ku, Jin-Mo, Jew, Sang-sup
Format: Article
Language:English
Subjects:
Phase-transfer catalytic alkylation
Solid-phase synthesis
α-Amino acid
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Summary:[Display omitted] A solid supported glycineimine t-butyl ester was designed and successfully applied to the synthesis of (±)-α-amino acids. The phase-transfer catalytic alkylation, followed by acidic hydrolysis and benzoylation gave N-benzoyl-α-amino acid tert-butyl esters in high yields (up to 92%).
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.11.020