A convenient method for the preparation of primary amines using tritylamine

A convenient method for the preparation of primary amines from alkyl halides or alkyl tosylates by the use of tritylamine has been established. Primary amines were obtained in good yields by treating the N-tritylamines with trifluoroacetic acid. A simple method for the preparation of primary amines...

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Bibliographic Details
Published in:Tetrahedron letters 2005-02, Vol.46 (8), p.1357-1360
Main Authors: Theodorou, Vassiliki, Ragoussis, Valentine, Strongilos, Alexandros, Zelepos, Evangelos, Eleftheriou, Argyro, Dimitriou, Maria
Format: Article
Language:English
Subjects:
Aminating agent
Amination
Ammonia synthon
Primary amines
Tritylamide
Tritylamine
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Summary:A convenient method for the preparation of primary amines from alkyl halides or alkyl tosylates by the use of tritylamine has been established. Primary amines were obtained in good yields by treating the N-tritylamines with trifluoroacetic acid. A simple method for the preparation of primary amines by treating N-tritylamines with trifluoroacetic acid has been established. The N-tritylamines were prepared by the reaction of alkyl halides or alkyl p-toluenesulfonates with tritylamine, or by the reaction of alkyl bromides with lithium tritylamide.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.12.098