A modified procedure for the Dakin–West reaction: an efficient and convenient method for a one-pot synthesis of β-acetamido ketones using silica sulfuric acid as catalyst

[Display omitted] A one-pot, four-component condensation of an aryl aldehyde, an aryl ketone, acetyl chloride and acetonitrile in the presence of silica sulfuric acid as an active, inexpensive, recoverable and recyclable catalyst is disclosed for the synthesis of β-acetamido ketones.

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Bibliographic Details
Published in:Tetrahedron letters 2005-03, Vol.46 (12), p.2105-2108
Main Authors: Khodaei, Mohammd M., Khosropour, Ahmad R., Fattahpour, Peyman
Format: Article
Language:English
Subjects:
Acetophenones
Benzaldehydes
Catalyst
Dakin–West reaction
One-pot synthesis
Silica sulfuric acid
β-Acetamido ketones
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Description
Summary:[Display omitted] A one-pot, four-component condensation of an aryl aldehyde, an aryl ketone, acetyl chloride and acetonitrile in the presence of silica sulfuric acid as an active, inexpensive, recoverable and recyclable catalyst is disclosed for the synthesis of β-acetamido ketones.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.01.149