The use of deep cavity tetraformyl calix[4]arenes in the synthesis of static and dynamic macrocyclic libraries

This paper reports the first synthesis of a number of deep cavity calix[4]arene macrocycles and illustrates their potential in the generation of static and dynamic combinatorial libraries based on reversible imine formation. This communication reports the first synthesis of a number of deep cavity t...

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Bibliographic Details
Published in:Tetrahedron letters 2005-03, Vol.46 (12), p.2059-2062
Main Authors: Kuhnert, Nikolai, Le-Gresley, Adam
Format: Article
Language:English
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Summary:This paper reports the first synthesis of a number of deep cavity calix[4]arene macrocycles and illustrates their potential in the generation of static and dynamic combinatorial libraries based on reversible imine formation. This communication reports the first synthesis of a number of deep cavity tetraformyl calix[4]arene macrocycles and their use as key building blocks in the synthesis of a dynamic and the first static non-peptide macrocyclic library.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.01.168