A direct method for the synthesis of nucleoside 5′-methylenebis(phosphonate)s from nucleosides

[Display omitted] An efficient method for the preparation of nucleoside 5′-methylenebis(phosphonate)s has been developed. Unprotected nucleosides are phosphonylated directly with methylenebis(phosphonic dichloride). Reaction conditions were optimized to prevent side product formation.

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Bibliographic Details
Published in:Tetrahedron letters 2005-04, Vol.46 (14), p.2417-2421
Main Authors: Kalek, Marcin, Jemielity, Jacek, Stepinski, Janusz, Stolarski, Ryszard, Darzynkiewicz, Edward
Format: Article
Language:English
Subjects:
Bisphosphonates
Nucleosides
Nucleotides
Synthesis
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Summary:[Display omitted] An efficient method for the preparation of nucleoside 5′-methylenebis(phosphonate)s has been developed. Unprotected nucleosides are phosphonylated directly with methylenebis(phosphonic dichloride). Reaction conditions were optimized to prevent side product formation.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.02.069