Cytotoxic cuparene sesquiterpenes from Laurencia microcladia

Three new cuparene sesquiterpenes 1– 3 were isolated from the organic extract of the red alga Laurencia microcladia, collected at Chios island in the North Aegean Sea, Greece. The structures and the relative stereochemistry of the compounds are proposed on the basis of their spectral data. Metabolit...

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Bibliographic Details
Published in:Tetrahedron letters 2005-08, Vol.46 (34), p.5723-5726
Main Authors: Kladi, Maria, Vagias, Constantinos, Furnari, Giovanni, Moreau, Dimitri, Roussakis, Christos, Roussis, Vassilios
Format: Article
Language:English
Subjects:
Cuparene
Cytotoxic
Laurencia microcladia
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Summary:Three new cuparene sesquiterpenes 1– 3 were isolated from the organic extract of the red alga Laurencia microcladia, collected at Chios island in the North Aegean Sea, Greece. The structures and the relative stereochemistry of the compounds are proposed on the basis of their spectral data. Metabolite 2 shows an unprecedented (for the cuparene class of sesquiterpenes) migration of the C-1 methyl group. All metabolites 1– 3 were found to exhibit significant cytotoxic activity against two lung cancer cell lines.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.06.076