Palladium-catalyzed intramolecular γ-lactam formation of an aryl halide and an enolate: synthesis of isoindolobenzazepine alkaloids, lennoxamine, 13-deoxychilenine, and chilenine

A facile synthetic path to isoindolobenzazepine alkaloids, lennoxamine, 13-deoxychilenine, and chilenine, was established by employing a palladium-catalyzed intramolecular α-arylation of the ketone, as the key step. A facile synthetic path to isoindolobenzazepine alkaloids, lennoxamine, 13-deoxychil...

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Bibliographic Details
Published in:Tetrahedron letters 2005-10, Vol.46 (40), p.6823-6825
Main Authors: Honda, Toshio, Sakamaki, Yoshiaki
Format: Article
Language:English
Subjects:
13-Deoxychilenine
Chilenine
Isoindolobenzazepine alkaloid
Lennoxamine
Palladium-catalyzed intramolecular α-arylation
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Summary:A facile synthetic path to isoindolobenzazepine alkaloids, lennoxamine, 13-deoxychilenine, and chilenine, was established by employing a palladium-catalyzed intramolecular α-arylation of the ketone, as the key step. A facile synthetic path to isoindolobenzazepine alkaloids, lennoxamine, 13-deoxychilenine, and chilenine, was established by employing a palladium-catalyzed intramolecular α-arylation of the ketone, as the key step.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.08.025