Regioselective thionocarbonation of ginkgolides: facile preparation of ginkgolide J

Ginkgolide J, a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract, can be readily prepared from an abundant ginkgolide C in two steps: thionocarbonation and subsequent deoxygenation. Regioselectivity of the first thionocarbonation step can be controlled by a proper choi...

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Bibliographic Details
Published in:Tetrahedron letters 2005-11, Vol.46 (45), p.7797-7799
Main Authors: Dzyuba, Sergei V., Bolshakov, Sergei, Nakanishi, Koji
Format: Article
Language:English
Subjects:
Deoxygenation
Ginkgo biloba
Ginkgolides
Regioselectivity
Thionocarbonation
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Summary:Ginkgolide J, a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract, can be readily prepared from an abundant ginkgolide C in two steps: thionocarbonation and subsequent deoxygenation. Regioselectivity of the first thionocarbonation step can be controlled by a proper choice of the base and solvent combination.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.09.022