Regioselective palladium-catalyzed phenylation of ethyl 4-oxazolecarboxylate

The highly regioselective palladium-catalyzed C-2 phenylation of ethyl 4-oxazolecarboxylate with phenyl iodide is described. The efficient and regioselective palladium-catalyzed C-2 arylation of ethyl 4-oxazolecarboxylate 1 with phenyliodide is described. The different parameters (solvent, base, lig...

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Bibliographic Details
Published in:Tetrahedron letters 2005-12, Vol.46 (49), p.8573-8577
Main Authors: Hoarau, Christophe, Du Fou de Kerdaniel, Alexis, Bracq, Nicolas, Grandclaudon, Pierre, Couture, Axel, Marsais, Francis
Format: Article
Language:English
Subjects:
Aryloxazoles
Direct coupling
Ethyl 4-oxazolecarboxylate
Palladium
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Summary:The highly regioselective palladium-catalyzed C-2 phenylation of ethyl 4-oxazolecarboxylate with phenyl iodide is described. The efficient and regioselective palladium-catalyzed C-2 arylation of ethyl 4-oxazolecarboxylate 1 with phenyliodide is described. The different parameters (solvent, base, ligand and catalyst) for the optimal conditions of this arylation process have been screened.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.09.192