Scandium triflate as an efficient and useful catalyst for the synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines under solvent-free conditions

A simple and efficient method has been developed for the synthesis of β-amino alcohols by ring opening of epoxides in the presence of a catalytic amount of Sc(OTf) 3 at room temperature under solvent-free conditions. The reaction works well with both aromatic and aliphatic amines. High regio-, and d...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2005-12, Vol.46 (52), p.9029-9034
Main Authors: Placzek, Andrew T., Donelson, James L., Trivedi, Rushi, Gibbs, Richard A., De, Surya K.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A simple and efficient method has been developed for the synthesis of β-amino alcohols by ring opening of epoxides in the presence of a catalytic amount of Sc(OTf) 3 at room temperature under solvent-free conditions. The reaction works well with both aromatic and aliphatic amines. High regio-, and diastereoselectivity can be considered as a noteworthy advantage of this method.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.10.106