A short synthesis of lennoxamine via ynamides

Lennoxamine was synthesized in eight steps from 2,3-dimethoxybenzoic acid via an intermediate ynamide by using palladium-catalyzed Heck–Suzuki–Miyaura domino reactions.

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Bibliographic Details
Published in:Tetrahedron letters 2006-01, Vol.47 (5), p.767-769
Main Authors: Couty, Sylvain, Meyer, Christophe, Cossy, Janine
Format: Article
Language:English
Subjects:
Isoindolinones
Isoindolobenzazepines
Lennoxamine
Palladium-catalyzed reactions
Suzuki–Miyaura coupling
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Description
Summary:Lennoxamine was synthesized in eight steps from 2,3-dimethoxybenzoic acid via an intermediate ynamide by using palladium-catalyzed Heck–Suzuki–Miyaura domino reactions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.11.093