Convenient multi-gram scale synthesis of polybrominated imidazoles building blocks

The multi-gram scale polybromination of variously substituted imidazoles has been realized using a stoichiometric amount of the Br2–DMF complex. Good yields have been obtained compared to other methods using large amounts of acetic acid–sodium acetate buffer.

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Bibliographic Details
Published in:Tetrahedron letters 2006-03, Vol.47 (12), p.1949-1951
Main Authors: Bahnous, Mebarek, Mouats, Chabane, Fort, Yves, Gros, Philippe C.
Format: Article
Language:English
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Summary:The multi-gram scale polybromination of variously substituted imidazoles has been realized using a stoichiometric amount of the Br2–DMF complex. Good yields have been obtained compared to other methods using large amounts of acetic acid–sodium acetate buffer.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.01.066