Synthesis of novel cyclopropylic sulfones and sulfonamides acting as glucokinase activators

A synthetic route towards cyclopropylic compounds, which act as glucokinase activators is described herein. The present synthesis gives easy and rapid access to a wide variety of either sulfones or sulfonamides starting from readily available late-stage intermediates.

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Bibliographic Details
Published in:Tetrahedron letters 2006-04, Vol.47 (16), p.2675-2678
Main Authors: Heuser, Stefan, Barrett, David G., Berg, Martina, Bonnier, Benjamin, Kahl, Astrid, De La Puente, Maria Luz, Oram, Niall, Riedl, Rainer, Roettig, Ulrike, Gil, Gema Sanz, Seger, Erich, Steggles, David J., Wanner, Jutta, Weichert, Andreas G.
Format: Article
Language:English
Subjects:
Cyclopropanes
Glucokinase activators
Halogen–sulfur exchange
Sulfonamides
Sulfones
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Description
Summary:A synthetic route towards cyclopropylic compounds, which act as glucokinase activators is described herein. The present synthesis gives easy and rapid access to a wide variety of either sulfones or sulfonamides starting from readily available late-stage intermediates.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.02.110