A facile microwave-assisted palladium-catalyzed cyanation of aryl chlorides

We report an efficient method for the preparation of aryl nitriles from aryl chlorides under either microwave assisted or thermal conditions. A catalyst system comprising tris(dibenzylidene acetone)dipalladium (Pd 2(dba) 3) and 2-(2′,6′-dimethoxybiphenyl)dicyclohexylphosphine (S-Phos) is shown to ef...

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Bibliographic Details
Published in:Tetrahedron letters 2006-05, Vol.47 (19), p.3303-3305
Main Authors: Chobanian, Harry R., Fors, Brett P., Lin, Linus S.
Format: Article
Language:English
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Summary:We report an efficient method for the preparation of aryl nitriles from aryl chlorides under either microwave assisted or thermal conditions. A catalyst system comprising tris(dibenzylidene acetone)dipalladium (Pd 2(dba) 3) and 2-(2′,6′-dimethoxybiphenyl)dicyclohexylphosphine (S-Phos) is shown to effectively promote cyanation of various aryl chlorides with Zn(CN) 2 as the cyanide source.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.03.026