PCP-Bis(phosphinite) pincer complexes: new homogeneous catalysts for α-arylation of ketones

Two new p-alkoxycarbonylated palladium bis(phosphinite) PCP pincer complexes are easily prepared and for the first time evaluated as homogeneous catalysts in α-arylation of ketone enolates. Apart from the total absence of phenyl–aryl exchange by-products and significantly low catalyst loadings, the...

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Bibliographic Details
Published in:Tetrahedron letters 2006-05, Vol.47 (19), p.3233-3237
Main Authors: Churruca, Fátima, SanMartin, Raul, Tellitu, Imanol, Domínguez, Esther
Format: Article
Language:English
Subjects:
Catalysis
Palladacycles
Pincer complexes
α-Arylation
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Summary:Two new p-alkoxycarbonylated palladium bis(phosphinite) PCP pincer complexes are easily prepared and for the first time evaluated as homogeneous catalysts in α-arylation of ketone enolates. Apart from the total absence of phenyl–aryl exchange by-products and significantly low catalyst loadings, the general α-arylation protocols described in this letter feature not only a broad applicability to a range of ketones and aryl bromides with marked electronic and steric differences but also the possibility to generate mono-diarylated products.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.03.040