Stereoselective synthesis of bis-hydroxy-tetrahydrofurans using cross metathesis

A short asymmetric approach for the synthesis of bis-tetrahydrofuran units of various annonaceous acetogenins is described. The key steps of the synthesis are self-cross metathesis and Sharpless asymmetric dihydroxylation.

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Bibliographic Details
Published in:Tetrahedron letters 2006-05, Vol.47 (20), p.3401-3403
Main Authors: Ramu, Errabelli, Bhaskar, G., Rao, B. Venkateswara, Ramanjaneyulu, G.S.
Format: Article
Language:English
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Description
Summary:A short asymmetric approach for the synthesis of bis-tetrahydrofuran units of various annonaceous acetogenins is described. The key steps of the synthesis are self-cross metathesis and Sharpless asymmetric dihydroxylation.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.03.080