Development of nonproprietary phosphine ligands for the Pd-catalyzed amination reaction

We have prepared a new family of pyrazole and bi-pyrazole phosphine ligands that perform efficiently in the Pd-catalyzed amination reaction. Of the ligands screened, ligand 1 is the most compatible for couplings involving both primary and secondary amines with typical yields of 84–99%. A new family...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2006-05, Vol.47 (22), p.3727-3731
Main Authors: Singer, Robert A., Doré, Michaël, Sieser, Janice E., Berliner, Martin A.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have prepared a new family of pyrazole and bi-pyrazole phosphine ligands that perform efficiently in the Pd-catalyzed amination reaction. Of the ligands screened, ligand 1 is the most compatible for couplings involving both primary and secondary amines with typical yields of 84–99%. A new family of pyrazole and bi-pyrazole phosphine ligands are reported that perform efficiently in the Pd-catalyzed amination reaction. Of the ligands screened, ligand 1 emerged as the most compatible for couplings involving both primary and secondary amines with typical yields of 84–99%.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.03.132