Studies directed towards the synthesis of antascomicin A: stereoselective synthesis of the C1–C21 fragment of the molecule

A stereoselective synthesis of the C1–C21 fragment of the non-immunosuppressive immunophilin-binding natural product, antascomicin A was achieved using, as key steps, highly stereoselective Aldol reactions to build the C1–C17 fragment and a Nozaki–Hiyama–Kishi reaction to couple it with the remainin...

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Bibliographic Details
Published in:Tetrahedron letters 2006-07, Vol.47 (29), p.4999-5002
Main Authors: Chakraborty, Tushar Kanti, Mohan, Bajjuri Krishna
Format: Article
Language:English
Subjects:
Antascomicin
FKBP12 binding ligand
Immunosuppressant
Takai reaction
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Summary:A stereoselective synthesis of the C1–C21 fragment of the non-immunosuppressive immunophilin-binding natural product, antascomicin A was achieved using, as key steps, highly stereoselective Aldol reactions to build the C1–C17 fragment and a Nozaki–Hiyama–Kishi reaction to couple it with the remaining C18–C21 moiety.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.05.113