Solvent-free reaction on KF-alumina under microwave: serendipitous one-pot domino synthesis of new isobenzofuran-1(3 H)-ones from alpha-hydroxyketones

The reaction of four α-hydroxyketones 1a– d with a double equivalent of t-butyl acetylacetonate in the presence of KF-alumina under microwave irradiation afforded 6-acetyl-5-hydroxy-3,3-dialkyl-7-methyl isobenzofuran-1(3 H)-ones 3a– d.

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Bibliographic Details
Published in:Tetrahedron letters 2006-07, Vol.47 (31), p.5519-5521
Main Authors: Villemin, Didier, Cheikh, Nawel, Mostefa-Kara, Bachir, Bar, Nathalie, Choukchou-Braham, Noureddine, Didi, Mohamed A.
Format: Article
Language:English
Subjects:
Isobenzofuran-1-(3 H)-ones
KF-alumina
Microwave
α-Hydroxyketone
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Summary:The reaction of four α-hydroxyketones 1a– d with a double equivalent of t-butyl acetylacetonate in the presence of KF-alumina under microwave irradiation afforded 6-acetyl-5-hydroxy-3,3-dialkyl-7-methyl isobenzofuran-1(3 H)-ones 3a– d.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.05.137