Modification of guanine residues in PNA-synthesis by PyBOP

The phosphonium-type coupling reagent PyBOP, when applied to the synthesis of peptide nucleic acid (PNA) oligomers, was found to form O 4-phosphonium compounds of the nucleobase guanine which can be converted into C 4-modified guanine-derived PNAs by nucleophiles.

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Bibliographic Details
Published in:Tetrahedron letters 2006-08, Vol.47 (33), p.5893-5896
Main Authors: Pritz, Stephan, Wolf, Yvonne, Klemm, Clementine, Bienert, Michael
Format: Article
Language:English
Subjects:
Coupling reagents
Guanine
HATU
PNA synthesis
PyBOP
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Summary:The phosphonium-type coupling reagent PyBOP, when applied to the synthesis of peptide nucleic acid (PNA) oligomers, was found to form O 4-phosphonium compounds of the nucleobase guanine which can be converted into C 4-modified guanine-derived PNAs by nucleophiles.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.06.069