epi-Aszonalenins A, B, and C from Aspergillus novofumigatus

Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis of...

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Bibliographic Details
Published in:Tetrahedron letters 2006-08, Vol.47 (34), p.6099-6102
Main Authors: Rank, Christian, Phipps, Richard Kerry, Harris, Pernille, Frisvad, Jens Christian, Gotfredsen, Charlotte Held, Larsen, Thomas Ostenfeld
Format: Article
Language:English
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Summary:Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis of a single crystal X-ray diffraction study of epi-aszonalenin A and the absolute configuration was determined by optical rotation comparison with the literature data. The absolute configurations of epi-aszonalenins B and C were determined by circular dichroism comparison to epi-aszonalenin A.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.06.086