Practical Cu-catalyzed amination of functionalized heteroaryl halides

The amination of a variety of highly functionalized heterocyclic bromides has been accomplished using a CuI/proline catalyst system. The current study significantly expanded the scope of the reaction by using examples relevant to drug discovery programs and has demonstrated reaction rate acceleratio...

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Bibliographic Details
Published in:Tetrahedron letters 2006-08, Vol.47 (34), p.6011-6016
Main Authors: Yeh, Vince S.C., Wiedeman, Paul E.
Format: Article
Language:English
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Summary:The amination of a variety of highly functionalized heterocyclic bromides has been accomplished using a CuI/proline catalyst system. The current study significantly expanded the scope of the reaction by using examples relevant to drug discovery programs and has demonstrated reaction rate acceleration using microwave heating.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.06.119