Convergent synthesis of a 24-membered macrocyclic hexaoxazole derivative related to the novel telomerase inhibitor telomestatin

An efficient construction of a 24-membered macrocyclic hexaoxazole derivative pertinent to the synthesis of analogues of the important natural product telomestatin was developed, which featured a convergent union of two trisoxazole units.

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Bibliographic Details
Published in:Tetrahedron letters 2006-11, Vol.47 (45), p.7897-7900
Main Authors: Chattopadhyay, Shital K., Biswas, Suman
Format: Article
Language:English
Subjects:
Cyclodehydration
Macrocycle
Oxazole
Oxidation
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Description
Summary:An efficient construction of a 24-membered macrocyclic hexaoxazole derivative pertinent to the synthesis of analogues of the important natural product telomestatin was developed, which featured a convergent union of two trisoxazole units.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.09.014