Synthesis and post-synthetic derivatization of a cyanine-based amino acid. Application to the preparation of a novel water-soluble NIR dye

An efficient synthesis of a new fluorescent amino acid derived from a pentamethylene cyanine dye is described. Selective derivatization of its amino group with an original trisulfonated linker has led to a novel water-soluble NIR dye suitable for covalent labeling of biomolecules

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Bibliographic Details
Published in:Tetrahedron letters 2006-11, Vol.47 (47), p.8279-8284
Main Authors: Chipon, Bertrand, Clavé, Guillaume, Bouteiller, Cédric, Massonneau, Marc, Renard, Pierre-Yves, Romieu, Anthony
Format: Article
Language:English
Subjects:
Cyanine dye
Fluorescent amino acid
Sulfonation
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Description
Summary:An efficient synthesis of a new fluorescent amino acid derived from a pentamethylene cyanine dye is described. Selective derivatization of its amino group with an original trisulfonated linker has led to a novel water-soluble NIR dye suitable for covalent labeling of biomolecules
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.09.100