Synthesis of soft alkyl phenolic ether prodrugs using Mitsunobu chemistry

The synthesis of soft alkyl phenolic ether prodrugs in excellent yields has been reported by coupling a phenol with a hydroxymethylimide using Mitsunobu chemistry. The imides used in this study include saccharin, phthalimide, succinimide and two other compounds containing acidic imide-like N–H group...

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Bibliographic Details
Published in:Tetrahedron letters 2006-12, Vol.47 (50), p.8981-8982
Main Authors: Majumdar, Susruta, Juntunen, Juha, Sivendran, Sashi, Bharti, Neelam, Sloan, K.B.
Format: Article
Language:English
Subjects:
Imide
Mitsunobu coupling
Phenolic ethers
Prodrugs
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Summary:The synthesis of soft alkyl phenolic ether prodrugs in excellent yields has been reported by coupling a phenol with a hydroxymethylimide using Mitsunobu chemistry. The imides used in this study include saccharin, phthalimide, succinimide and two other compounds containing acidic imide-like N–H groups, benzotriazole, and imidazole.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.09.162