A simple synthesis of cytotoxic endoperoxide lactones

A series of dihydrobenzofuran-2-one 3 have been submitted to various dienophiles: whereas maleic anhydride led only to the adducts 4a, b, singlet oxygen gave the expected new endoperoxide lactones 5a– d, 6 and 7a, b, three of them showing interesting cytotoxicity towards various cancer cell lines.

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Bibliographic Details
Published in:Tetrahedron letters 2006-12, Vol.47 (51), p.9053-9056
Main Authors: Aldeco-Pérez, Eugenia, Rudler, Henri, Parlier, Andrée, Alvarez, Cecilio, Apan, Maria Teresa, Herson, Patrick, Toscano, Alfredo
Format: Article
Language:English
Subjects:
Cycloadditions
Cytotoxicity
Endoperoxides
Lactones
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Description
Summary:A series of dihydrobenzofuran-2-one 3 have been submitted to various dienophiles: whereas maleic anhydride led only to the adducts 4a, b, singlet oxygen gave the expected new endoperoxide lactones 5a– d, 6 and 7a, b, three of them showing interesting cytotoxicity towards various cancer cell lines.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.10.093