An efficient synthesis of a new class of spiroheterocycles: diastereoselective synthesis of dihydropyrrolo[2,1- a]isoquinolines

Isoquinoline reacts with diaroylacetylenes in the presence of 1,3-dicarbonyl compounds in a one-pot reaction to afford functionalized spiropyrroloisoquinolines in 90–96% yields.

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Bibliographic Details
Published in:Tetrahedron letters 2007-09, Vol.48 (38), p.6709-6712
Main Authors: Yavari, Issa, Mokhtarporyani-Sanandaj, Ako, Moradi, Loghman
Format: Article
Language:English
Subjects:
1,3-Dicarbonyl compounds
Diaroylacetylenes
Isoquinoline
Pyrroloisoquinoline
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Description
Summary:Isoquinoline reacts with diaroylacetylenes in the presence of 1,3-dicarbonyl compounds in a one-pot reaction to afford functionalized spiropyrroloisoquinolines in 90–96% yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.07.135