Copper-catalysed benzofuran synthesis: developing aryl bromide–alkenyl triflates as general heterocycle precursors

A range of conjugated aryl bromide–alkenyl triflates are efficiently converted to the corresponding benzofurans when treated with CuI/TMEDA and potassium hydroxide. A range of conjugated aryl bromide–alkenyl triflates, previously described as indole precursors, are efficiently converted to the corre...

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Bibliographic Details
Published in:Tetrahedron letters 2007-10, Vol.48 (43), p.7578-7581
Main Authors: Tadd, Andrew C., Fielding, Mark R., Willis, Michael C.
Format: Article
Language:English
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Summary:A range of conjugated aryl bromide–alkenyl triflates are efficiently converted to the corresponding benzofurans when treated with CuI/TMEDA and potassium hydroxide. A range of conjugated aryl bromide–alkenyl triflates, previously described as indole precursors, are efficiently converted to the corresponding benzofurans when treated with CuI/TMEDA and potassium hydroxide.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.08.109