Base-free monosulfonylation of amines using tosyl or mesyl chloride in water

A mild and efficient procedure has been developed for the monosulfonylation of various amines using mesyl or tosyl chlorides in water at room temperature to afford the corresponding sulfonamides in high yields.

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Bibliographic Details
Published in:Tetrahedron letters 2008-01, Vol.49 (2), p.348-353
Main Authors: Kamal, Ahmed, Reddy, J. Surendranadha, Bharathi, E. Vijaya, Dastagiri, D.
Format: Article
Language:English
Subjects:
Amines
Methanesulfonyl chloride
p-Toluenesulfonyl chloride
Sulfonamides
Water
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Description
Summary:A mild and efficient procedure has been developed for the monosulfonylation of various amines using mesyl or tosyl chlorides in water at room temperature to afford the corresponding sulfonamides in high yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.11.044