Carbohydrates in asymmetric synthesis: enantioselective allylation of aldehydes

An enantioselective metal-mediated addition of allylic bromides to carbonyl compounds was achieved in the presence of the inexpensive and easily accessible carbohydrates saccharose and β-cyclodextrin. The desired products were obtained in moderate to excellent yields and with up to 93% enantiomeric...

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Bibliographic Details
Published in:Tetrahedron letters 2008-08, Vol.49 (33), p.4956-4957
Main Authors: Appelt, Helmoz R., Limberger, Jane B., Weber, Minéia, Rodrigues, Oscar E.D., Oliveira, Julieta S., Lüdtke, Diogo S., Braga, Antonio L.
Format: Article
Language:English
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Summary:An enantioselective metal-mediated addition of allylic bromides to carbonyl compounds was achieved in the presence of the inexpensive and easily accessible carbohydrates saccharose and β-cyclodextrin. The desired products were obtained in moderate to excellent yields and with up to 93% enantiomeric excess.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2008.05.109