Microwave-assisted three-component Knoevenagel-nucleophilic aromatic substitution reactions

A powerful microwave-assisted three-component Knoevenagel-nucleophilic aromatic substitution reaction of 4-halobenzaldehydes, cyanoacetatic acid esters/cyanoacetamides, and cyclic secondary amines has been developed.

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Bibliographic Details
Published in:Tetrahedron letters 2008-08, Vol.49 (32), p.4687-4689
Main Authors: Xu, Hui, Yu, Xinhong, Sun, Leying, Liu, Jing, Fan, Wen, Shen, Yongjia, Wang, Wei
Format: Article
Language:English
Subjects:
4-Halobenzaldehyde
Microwave-assisted reaction
S NAr
Three-component reaction
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Description
Summary:A powerful microwave-assisted three-component Knoevenagel-nucleophilic aromatic substitution reaction of 4-halobenzaldehydes, cyanoacetatic acid esters/cyanoacetamides, and cyclic secondary amines has been developed.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2008.05.122