Synthesis of indolylalkylphosphonates and 3-(1-diphenylphosphinoalkyl) indoles by reaction of 3-(1-arylsulfonylalkyl) indoles with phosphorus derivatives

Dialkyl phosphites as well as diphenylphosphine react with 3-(1-arylsulfonylalkyl) indoles under basic conditions leading to a formal substitution of the arylsulfonyl group through a reactive 3-alkyliden indole intermediate. Dialkyl phosphites as well as diphenylphosphine react with 3-(1-arylsulfony...

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Bibliographic Details
Published in:Tetrahedron letters 2008-09, Vol.49 (39), p.5645-5648
Main Authors: Petrini, Marino, Shaikh, Rafik R.
Format: Article
Language:English
Subjects:
Conjugate addition
Imines
Indoles
Phosphines
Phosphites
Sulfones
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Summary:Dialkyl phosphites as well as diphenylphosphine react with 3-(1-arylsulfonylalkyl) indoles under basic conditions leading to a formal substitution of the arylsulfonyl group through a reactive 3-alkyliden indole intermediate. Dialkyl phosphites as well as diphenylphosphine react with 3-(1-arylsulfonylalkyl) indoles under basic conditions leading to a formal substitution of the arylsulfonyl group through a reactive 3-alkylidene indole intermediate.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2008.07.077