Expeditious formation of γ-lactones upon palladium-catalyzed double nucleophilic addition of bis(TMS)ketene acetals to vicinal allylacetates

Polysubstituted γ-lactones are easily obtained, in one step, upon the interaction of bis(TMS)ketene acetals with vicinal allylic acetates in the presence of catalytic amounts of Pd(PPh 3) 4.

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Bibliographic Details
Published in:Tetrahedron letters 2008-10, Vol.49 (41), p.5843-5846
Main Authors: Chavez, Cesar Sandoval, Rudler, Henri, Parlier, Andrée, Herson, Patrick
Format: Article
Language:English
Subjects:
Allyl acetates
Double nucleophilic additions
Ketene acetals
Lactones
Palladium-catalysis
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Description
Summary:Polysubstituted γ-lactones are easily obtained, in one step, upon the interaction of bis(TMS)ketene acetals with vicinal allylic acetates in the presence of catalytic amounts of Pd(PPh 3) 4.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2008.07.111