Synthesis of cyclopropanes by Pd-catalyzed activation of alkyl C–H bonds

A novel synthesis of cyclopropanes has been developed via palladium-catalyzed C–H activation in which two new carbon–carbon bonds are formed in a single step. This method involves palladium-catalyzed activation of normally unreactive secondary alkyl C–H bonds and provides an efficient way to access...

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Bibliographic Details
Published in:Tetrahedron letters 2009-12, Vol.50 (52), p.7235-7238
Main Authors: Huang, Qinhua, Larock, Richard C.
Format: Article
Language:English
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Summary:A novel synthesis of cyclopropanes has been developed via palladium-catalyzed C–H activation in which two new carbon–carbon bonds are formed in a single step. This method involves palladium-catalyzed activation of normally unreactive secondary alkyl C–H bonds and provides an efficient way to access cyclopropapyrrolo[1,2- a]indoles, analogues of mitomycin and cyclopropamitosenes. A novel synthesis of cyclopropanes has been developed via palladium-catalyzed C–H activation in which two new carbon–carbon bonds are formed in a single step. This method involves palladium-catalyzed activation of normally unreactive secondary alkyl C–H bonds and provides an efficient way to access cyclopropapyrrolo[1,2- a]indoles, analogues of mitomycin and cyclopropamitosenes.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.10.013