First synthesis of 2,6-diazabicyclo[3.2.0]heptane derivatives

The first synthesis of 6-phenyl-2,6-diazabicyclo[3.2.0]heptane 1 and its orthogonally protected precursor 2 is herein reported. Our strategy enables to chemically address the two nitrogen atoms of 2,6-diazabicyclo[3.2.0]heptane core individually and selectively, thus allowing rapid access to several...

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Bibliographic Details
Published in:Tetrahedron letters 2009-12, Vol.50 (52), p.7280-7282
Main Authors: Napolitano, Carmela, Borriello, Manuela, Cardullo, Francesca, Donati, Daniele, Paio, Alfredo, Manfredini, Stefano
Format: Article
Language:English
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Summary:The first synthesis of 6-phenyl-2,6-diazabicyclo[3.2.0]heptane 1 and its orthogonally protected precursor 2 is herein reported. Our strategy enables to chemically address the two nitrogen atoms of 2,6-diazabicyclo[3.2.0]heptane core individually and selectively, thus allowing rapid access to several subsets of widely substituted fused azetidines.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.10.028