Alkoxide-induced nucleophilic trifluoromethylation using diethyl trifluoromethylphosphonate

A novel alkoxide-induced nucleophilic trifluoromethylation of carbonyl compounds, disulfides, and diselenides using diethyl trifluoromethylphosphonate is presented. In these reactions diethyl trifluoromethylphosphonate acts as a [ CF 3 - ] synthon.

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Bibliographic Details
Published in:Tetrahedron letters 2010-01, Vol.51 (2), p.252-255
Main Authors: Cherkupally, Prabhakar, Beier, Petr
Format: Article
Language:English
Subjects:
Nucleophilic addition
Phosphonate
Trifluoromethylation
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Description
Summary:A novel alkoxide-induced nucleophilic trifluoromethylation of carbonyl compounds, disulfides, and diselenides using diethyl trifluoromethylphosphonate is presented. In these reactions diethyl trifluoromethylphosphonate acts as a [ CF 3 - ] synthon.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.10.135