Convenient synthesis of bis(indolyl)alkanes and bis(pyrrolyl)alkanes by Cu(OTf) 2-catalyzed addition of indole and pyrrole to acetylenic sulfone

Sulfonyl-containing bis(indolyl)alkanes and bis(pyrrolyl)alkanes were synthesized conveniently by Cu(OTf) 2-catalyzed double Michael addition of indole and pyrrole to acetylenic sulfone. Sulfonyl-containing bis(indolyl)alkanes and bis(pyrrolyl)alkanes were synthesized conveniently by Cu(OTf) 2-catal...

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Bibliographic Details
Published in:Tetrahedron letters 2010-02, Vol.51 (8), p.1213-1215
Main Authors: Xie, Mei-Hua, Xie, Fa-Dong, Lin, Gao-Feng, Zhang, Jin-Hua
Format: Article
Language:English
Subjects:
Bis(indolyl)alkanes
Bis(pyrrolyl)alkanes
Cu(OTf) 2
Michael addition
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Summary:Sulfonyl-containing bis(indolyl)alkanes and bis(pyrrolyl)alkanes were synthesized conveniently by Cu(OTf) 2-catalyzed double Michael addition of indole and pyrrole to acetylenic sulfone. Sulfonyl-containing bis(indolyl)alkanes and bis(pyrrolyl)alkanes were synthesized conveniently by Cu(OTf) 2-catalyzed double Michael addition of indole and pyrrole to acetylenic sulfone.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.12.093