A very simple and highly efficient procedure for N-formylation of primary and secondary amines at room temperature under solvent-free conditions

A very simple, highly efficient and cost-effective method for N-formylation of primary and secondary amines in excellent yield using catalytic amount of sodium formate in formic acid under solvent-free conditions is reported. N-Formylation of primary and secondary amines has efficiently been carried...

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Bibliographic Details
Published in:Tetrahedron letters 2010-04, Vol.51 (17), p.2319-2322
Main Authors: Brahmachari, Goutam, Laskar, Sujay
Format: Article
Language:English
Subjects:
Amines
Formic acid
N-Formylation
Room temperature
Sodium formate
Solvent-free
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Summary:A very simple, highly efficient and cost-effective method for N-formylation of primary and secondary amines in excellent yield using catalytic amount of sodium formate in formic acid under solvent-free conditions is reported. N-Formylation of primary and secondary amines has efficiently been carried out at room temperature in excellent yields by using catalytic amount of sodium formate in formic acid under solvent-free conditions. The process is remarkably simple and environmentally benign.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.02.119