Bisleucocurine A, a novel bisindole alkaloid from Leuconotis griffithii

A novel bisindole alkaloid, bisleucocurine A ( 1), consisting of two strychnan skeletons with an N-1–C-17′ and a C-12–C-2′ bridges was isolated from the leaves of Leuconotis griffithii and the structure was elucidated on the basis of spectroscopic data. Bisleucocurine A ( 1) showed cytotoxicity agai...

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Bibliographic Details
Published in:Tetrahedron letters 2010-05, Vol.51 (19), p.2589-2592
Main Authors: Nugroho, Alfarius E., Hirasawa, Yusuke, Hosoya, Takahiro, Awang, Khalijah, Hadi, A. Hamid A., Morita, Hiroshi
Format: Article
Language:English
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Summary:A novel bisindole alkaloid, bisleucocurine A ( 1), consisting of two strychnan skeletons with an N-1–C-17′ and a C-12–C-2′ bridges was isolated from the leaves of Leuconotis griffithii and the structure was elucidated on the basis of spectroscopic data. Bisleucocurine A ( 1) showed cytotoxicity against various human cancer cell lines. A novel bisindole alkaloid, bisleucocurine A ( 1), consisting of two strychnan skeletons with an N-1–C-17′ and a C-12–C-2′ bridges, was isolated from the leaves of Leuconotis griffithii and the structure was elucidated on the basis of spectroscopic data. Bisleucocurine A ( 1) showed cytotoxicity against various human cancer cell lines.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.02.126