Synthesis and in vitro studies of Gd–DTPA derivatives as new potential MRI contrast agents

Gd–DTPA–bis-XDA ( 1) was prepared and evaluated as MRI contrast agent on the basis of r 1 value. A new type of dendritic molecules, Gd–DTPA derivatives, which work as a functionalized ligand coordinating gadolinium(III) ion at the center of their frameworks with different terminal moieties on the mo...

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Bibliographic Details
Published in:Tetrahedron letters 2010-05, Vol.51 (18), p.2431-2433
Main Authors: Sankar, Arigala Uma Ravi, Yamasitha, Mitsuji, Srinivasulu, Kambam, Ozaki, Nobuhisa, Aoki, Takashi, Fujie, Michio, Ogawa, Keisuke, Okada, Shingo, Yamada, Manubu, Tanaka, Yasutaka, Kimura, Motohiko, Toda, Mitsuo
Format: Article
Language:English
Subjects:
Dendritic ligands
Gd-complexes
MRI contrast agents
T1 and r1 values
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Summary:Gd–DTPA–bis-XDA ( 1) was prepared and evaluated as MRI contrast agent on the basis of r 1 value. A new type of dendritic molecules, Gd–DTPA derivatives, which work as a functionalized ligand coordinating gadolinium(III) ion at the center of their frameworks with different terminal moieties on the molecular surfaces, was readily synthesized with high yield. The structures were established by 1H, 13C NMR, and mass spectral studies. In vitro studies showed them to have enhanced r 1 value in albumin medium and good potentiality as MRI contrast agent.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.02.138