Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44

The total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44 are described and their cytotoxic activity in a cervical cancer (HeLa) cell line and human umbilical vein endothelial cells (HUVECs) are reported.

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Bibliographic Details
Published in:Tetrahedron letters 2010-09, Vol.51 (37), p.4812-4814
Main Authors: Shearman, James W., Myers, Rebecca M., Beale, Thomas M., Brenton, James D., Ley, Steven V.
Format: Article
Language:English
Subjects:
5-Bromoverongamine
Anticancer
Bromotyrosine
Ianthelline
JBIR-44
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Description
Summary:The total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44 are described and their cytotoxic activity in a cervical cancer (HeLa) cell line and human umbilical vein endothelial cells (HUVECs) are reported.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.07.016