One-pot copper-catalyzed synthesis of N-functionalized pyrazoles from boronic acids

A variety of N-aryl pyrazoles difficult to access via conventional methods were formed in a one-pot copper-catalyzed boronic acid coupling and cyclization protocol. A straight-forward route to prepare a diverse set of N-aryl pyrazoles via a one-pot copper-catalyzed boronic acid coupling and cyclizat...

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Bibliographic Details
Published in:Tetrahedron letters 2010, Vol.51 (38), p.5005-5008
Main Authors: Beveridge, Ramsay E., Fernando, Dilinie, Gerstenberger, Brian S.
Format: Article
Language:English
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Summary:A variety of N-aryl pyrazoles difficult to access via conventional methods were formed in a one-pot copper-catalyzed boronic acid coupling and cyclization protocol. A straight-forward route to prepare a diverse set of N-aryl pyrazoles via a one-pot copper-catalyzed boronic acid coupling and cyclization protocol is presented. A variety of aryl and heteroaryl N-functionalized pyrazoles not easily accessible by other means were formed in good yield from readily available boronic acid precursors in an operationally simple procedure.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.07.077