A new one-pot solvent-free synthesis of pyridinyl tosylates via diazotization of aminopyridines

A new, convenient, one-pot method for the synthesis of pyridinyl tosylates is developed. The procedure involves sequential diazotization/tosylation of aminopyridines with sodium nitrite and p-toluenesulfonic acid under solvent-free conditions in a water paste at room temperature.

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Bibliographic Details
Published in:Tetrahedron letters 2011-01, Vol.52 (1), p.85-87
Main Authors: Tretyakov, Alexey N., Krasnokutskaya, Elena A., Gorlushko, Dmitry A., Ogorodnikov, Vladimir D., Filimonov, Victor D.
Format: Article
Language:English
Subjects:
chemical reactions
pyridines
sodium nitrite
temperature
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Description
Summary:A new, convenient, one-pot method for the synthesis of pyridinyl tosylates is developed. The procedure involves sequential diazotization/tosylation of aminopyridines with sodium nitrite and p-toluenesulfonic acid under solvent-free conditions in a water paste at room temperature.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.10.163