Microwave assisted catalyst-free synthesis of azaarene-substituted 3-hydroxy-2-oxindoles by the functionalization of sp3 C–H bond in methyl pyridine

A highly efficient synthesis of azaarene-substituted 3-hydroxy-2-oxindoles in catalyst-free conditions is described by the reaction of 2-methyl pyridines with isatins under microwave irradiation in aqueous medium. Simple reaction conditions, high yields of the products and environmentally benign med...

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Bibliographic Details
Published in:Tetrahedron letters 2012-08, Vol.53 (31), p.3963-3966
Main Authors: Meshram, H.M., Nageswara Rao, N., Chandrasekhara Rao, L., Satish Kumar, N.
Format: Article
Language:English
Subjects:
Catalyst free conditions
Isatin
Methyl pyridine
Microwave
Water
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Summary:A highly efficient synthesis of azaarene-substituted 3-hydroxy-2-oxindoles in catalyst-free conditions is described by the reaction of 2-methyl pyridines with isatins under microwave irradiation in aqueous medium. Simple reaction conditions, high yields of the products and environmentally benign medium are attractive features of the present protocol.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.05.077