Supported copper triflate as an efficient catalytic system for the synthesis of highly functionalized 2-naphthol Mannich bases under solvent free condition

Various heterogeneous catalysts (Lewis acid) have been prepared and screened for the synthesis of Betti bases in an attempt to reduce the environmental hazards associated with the conventional homogeneous Lewis acid system. And we found especially Cu(OTf)2·SiO2 catalyzes the three-component coupling...

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Bibliographic Details
Published in:Tetrahedron letters 2012-08, Vol.53 (33), p.4376-4380
Main Authors: Dindulkar, Someshwar D., Puranik, Vedavati G., Jeong, Yeon Tae
Format: Article
Language:English
Subjects:
Betti bases
Single-crystal XRD
Solvent-free
Supported copper triflate
Three-component coupling
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Summary:Various heterogeneous catalysts (Lewis acid) have been prepared and screened for the synthesis of Betti bases in an attempt to reduce the environmental hazards associated with the conventional homogeneous Lewis acid system. And we found especially Cu(OTf)2·SiO2 catalyzes the three-component coupling of aldehyde, 2-naphthol, and alicyclic amine to generate Betti base with high efficiency under neat conditions without additional co-catalyst or additive in air. The reaction is not sensitive to water and occurs smoothly in water as well.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.06.022