Graphite catalyzed green synthesis of quinoxalines

A new simple approach using environmentally benign, cheap, and easily recyclable graphite as a heterogeneous catalyst for the synthesis of quinoxalines is described. A library of pharmacologically interesting diphenylquinoxalines is prepared by the double condensation of substituted benzils, phenant...

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Bibliographic Details
Published in:Tetrahedron letters 2013-02, Vol.54 (8), p.1003-1007
Main Authors: Kadam, Hari K., Khan, Salman, Kunkalkar, Rupesh A., Tilve, Santosh G.
Format: Article
Language:English
Subjects:
Graphite
Green chemistry
Quinoxalines
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Summary:A new simple approach using environmentally benign, cheap, and easily recyclable graphite as a heterogeneous catalyst for the synthesis of quinoxalines is described. A library of pharmacologically interesting diphenylquinoxalines is prepared by the double condensation of substituted benzils, phenanthrene-9,10-dione, and benzoin with aromatic diamines in 71–93% yields at room temperature in ethanol. Aliphatic diamines gave corresponding dihydropyrazines from substituted benzils in 72–92% yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.12.041