Iron-catalyzed carbonylation–arylation of N-arylacrylamides for synthesis of oxindole derivatives

An efficient method for oxindole synthesis is established by iron-catalyzed carbonylation–arylation of N-arylacrylamides with aldehydes. 3-Functionalized oxindoles are synthesized smoothly using FeCl3 as catalyst and TBHP as oxidant. The obtained oxindoles can be used for further transformations to...

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Bibliographic Details
Published in:Tetrahedron letters 2013-11, Vol.54 (47), p.6337-6340
Main Authors: Jia, Fan, Liu, Kaisheng, Xi, Hui, Lu, Shenglin, Li, Zhiping
Format: Article
Language:English
Subjects:
Arylation
Carbonylation
Iron catalysis
Oxindoles
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Summary:An efficient method for oxindole synthesis is established by iron-catalyzed carbonylation–arylation of N-arylacrylamides with aldehydes. 3-Functionalized oxindoles are synthesized smoothly using FeCl3 as catalyst and TBHP as oxidant. The obtained oxindoles can be used for further transformations to give diverse indole alkaloid structure motifs.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.09.048