New naphthoquinone and monoterpenoid from Plumbago zeylanica

[Display omitted] New naphthoquinone 2 and new monoterpenoid 3 were isolated from the stems of Plumbago zeylanica, and their structures were determined on the basis of 2D NMR spectroscopy. Absolute configuration of 3 was established by synthesis of its enantiomer. The new naphthoquinone 2 showed pot...

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Bibliographic Details
Published in:Tetrahedron letters 2014-11, Vol.55 (48), p.6554-6556
Main Authors: Ohira, Susumu, Yokogawa, Yoshiaki, Tsuji, Shinji, Mitsui, Taichi, Fukukawa, Tatsuhiko, Hayashi, Ken-ichiro, Kuboki, Atsuhito, Matsuura, Nobuyasu, Iinuma, Munekazu, Nozaki, Hiroshi
Format: Article
Language:English
Subjects:
Absolute configuration
Chiral synthesis
Monoterpenoid
Naphthoquinone
Nuclear factor κB
Plumbago zeylanica
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Summary:[Display omitted] New naphthoquinone 2 and new monoterpenoid 3 were isolated from the stems of Plumbago zeylanica, and their structures were determined on the basis of 2D NMR spectroscopy. Absolute configuration of 3 was established by synthesis of its enantiomer. The new naphthoquinone 2 showed potent inhibitory activity against nuclear factor κB (NF-κB), equivalent to that of parthenolide, a known potent inhibitor of NF-κB.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.10.016